Research project

Prof R. Read: MRC Experimental Human Challenge with Genetically Modified Commensals to Investigate Respiratory Tract Mucosal Immunity and Colonisation

Lead researchers:

Professor Robert Read
Other researchers:

Emeritus Professor Ian Clarke,

Professor Saul Faust
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researchers

Professor Robert Read

Chair of Infectious Diseases

Connect with Robert

Email: R.C.Read@soton.ac.uk

Other researchers

Emeritus Professor Ian Clarke

Research interests

Transposon mutagenesis of Chlamydia species
Cell culture systems and replicons for human noroviruses

Connect with Ian

Email: inc@soton.ac.uk

Professor Saul Faust MBBS, FRCPCH, PhD, FHEA, OBE

Professor Paediatric Immunology & Infect

Connect with Saul

Email: s.faust@soton.ac.uk

Research outputs

Controlled human infection with Bordetella pertussis induces asymptomatic, immunising colonisation

Hans de Graaf, Muktar Ibrahim, Alison R Hill, Diane Gbesemete, Andrew T Vaughan, Andrew Gorringe, Andrew Preston, Annemaire M Buisman, Saul Faust, Kent E. Kester, Guy Berbers, Dimitri A. Diavatopoulos & Robert Read, 2020, Clinical Infectious Diseases, 71(2), 403-411

DOI: 10.1093/cid/ciz840

Type: article

Exploring the acceptability of controlled human infection with SARSCoV2 – a public consultation

Diane Gbesemete, Mary Barker, Wendy Lawrence, Daniella Watson, Hans De Graaf & Robert Read, 2020, BMC Medicine, 18(1), 1-8

DOI: 10.1186/s12916-020-01670-2

Type: article

Neisseria meningitidis and meningococcal disease

Robert C Read, 2019, Current Opinion in Infectious Diseases, 32(6), 601-608

DOI: 10.1097/QCO.0000000000000606

Type: review

The nonpathogenic commensal Neisseria

Robert B Dorey, Anastasia A Theodosiou, Robert C Read & Christine E Jones, 2019, Current Opinion in Infectious Diseases, 32(5), 490-496

DOI: 10.1097/QCO.0000000000000585

Type: review

Alveolar macrophage apoptosis-associated bacterial killing helps prevent murine pneumonia

Julie A. Preston, Martin A. Bewley, Helen M. Marriott, A. McGarry Houghton, Mohamed Mohasin, Jamil Jubrail, Lucy Morris, Yvonne L. Stephenson, Simon Cross, David R. Greaves, Ruth W. Craig, Nico van Rooijen, Colin D. Bingle, Robert C. Read, Timothy J. Mitchell, Moira K. B. Whyte, Steven D. Shapiro & David H. Dockrell, 2019, American Journal of Respiratory and Critical Care Medicine, 200(1), 84-97

DOI: 10.1164/rccm.201804-0646OC

Type: article

Protocol for a controlled human infection with genetically modified Neisseria lactamica expressing the meningococcal vaccine antigen NadA

Diane Gbesemete, Jay Robert Laver, Hans de Graaf, Muktar Ibrahim, Andrew Vaughan, Saul Faust, Andrew Gorringe & Robert Charles Read, 2019, BMJ Open, 9(4), e026544

DOI: 10.1136/bmjopen-2018-026544

Type: article

Genomes of Escherichia coli bacteraemia isolates originating from urinary tract foci contain more virulence-associated genes than those from non-urinary foci and neutropaenic hosts

Adam P. Dale, Anish K. Pandey, Richard J. Hesp, Konstantinos Belogiannis, Jay R. Laver, Clifford C. Shone & Robert C. Read, 2018, Journal of Infection, 77(6), 534-543

DOI: 10.1016/j.jinf.2018.10.011

Type: article