Research project

Dr M Christodoulides - The Adhesin Complex Protein (ACP) of Neisseria meningitidis

Lead researchers:

Professor Myron Christodoulides
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researchers

Professor Myron Christodoulides

Professor of Bacteriology

Connect with Myron

Email: M.Christodoulides@soton.ac.uk

Research outputs

Characterization of two putative Dichelobacter nodosus footrot vaccine antigens identifies the first lysozyme inhibitor in the genus

Maria Victoria Humbert, Alexandra Jackson, Christian M. Orr, Ivo Tews & Myron Christodoulides, 2019, Scientific Reports, 9(1), 1-14

DOI: 10.1038/s41598-019-46506-z

Type: article

Structure of the recombinant Neisseria gonorrhoeae adhesin complex protein (rNg-ACP) and generation of murine antibodies with bactericidal activity against gonococci

Hannia, Liliana Almonacid Mendoza, Maria Humbert, Aiste Dijokaite, David Cleary, Yiwen Soo, Miao-chiu Hung, Christian M. Orr, Ivo Tews & Moritz M. Machelett, 2018, mSphere, 10(3), 1-25

DOI: 10.1128/mSphere.00331-18

Type: article

Neisseria gonorrhoeae employs two protein inhibitors to evade killing by human lysozyme

Stephanie A. Ragland, Maria V. Humbert, Myron Christodoulides & Alison K. Criss, 2018, PLOS Pathogens, 14(7)

DOI: 10.1371/journal.ppat.1007080

Type: article

Immunization with recombinant truncated Neisseria meningitidis-Macrophage Infectivity Potentiator (rT-Nm-MIP) protein induces murine antibodies that are cross-reactive and bactericidal for Neisseria gonorrhoeae

Maria Humbert & Myron Christodoulides, 2018, Vaccine

DOI: 10.1016/j.vaccine.2018.05.069

Type: article

Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor.

Maria Humbert, Amaka Awanye, Li Lian, Jeremy Derrick & Myron Christodoulides, 2017, PLOS Pathogens, 13(6)

DOI: 10.1371/journal.ppat.1006448

Type: article

Novel approaches to Neisseria meningitidis vaccine design

Myron Christodoulides & John Heckels, 2017, Pathogens and Disease, 75(3)

DOI: 10.1093/femspd/ftx033

Type: article

Vaccine potential of bacterial macrophage infectivity potentiator (MIP)-like peptidyl prolyl cis/trans isomerase (PPIase) proteins

María Victoria Humbert, Hannia L. Almonacid Mendoza, Alexandra C. Jackson, Miao-Chiu Hung, Magdalena K. Bielecka, John E. Heckels & Myron Christodoulides, 2015, Expert Review of Vaccines, 14(12), 1633-49

DOI: 10.1586/14760584.2015.1095638

Type: review