Research Research groups Member of: Clinical Neurosciences Research projects Active projects Novel Therapeutics for Vision Loss associated with Albinism Researchers: Doctor Helena Lee Doctor James Self , Doctor Arjuna Ratnayaka , Doctor Matthias Baud , Doctor Eloise Keeling Completed projects Medium through-put drug discovery for albinism Researchers: Doctor Eloise Keeling Doctor James Self Sponsor: Fight for Sight Publications 30 publications Page 3 of 3 An in-vitro cell model of intracellular protein aggregation provides insights into RPE stress associated with retinopathy Eloise Keeling, Annabelle J Culling, David A Johnston, David S Chatelet, Anton Page, David A Tumbarello, Andrew J Lotery & J Arjuna Ratnayaka, 2020, International Journal of Molecular Sciences, 21(18) DOI: 10.3390/ijms21186647 Type: article Oxidative stress and dysfunctional intracellular traffic linked to an unhealthy diet results in impaired cargo transport in the Retinal Pigment Epithelium (RPE) Eloise Keeling, David Chatelet, David Johnston, Anton Page, David Tumbarello, Andrew Lotery & J. Arjuna Ratnayaka, 2019, Molecular Nutrition & Food Research, 63(15) DOI: 10.1002/mnfr.201800951 Type: article A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy Paul Ibbett, Srinivas V. Goverdhan, Elena Pipi, Joe Kirit Chouhan, Eloise Keeling, Elizabeth M. Angus, Jenny Scott, Maureen Gatherer, Anton Page, Jessica Teeling, Andrew Lotery & J. Arjuna Ratnayaka, 2019, Scientific Reports, 9 DOI: 10.1038/s41598-019-43906-z Type: article Study of intracellular cargo trafficking and co-localization in the phagosome and autophagy-lysosomal pathways of Retinal Pigment Epithelium (RPE) cells J. Arjuna Ratnayaka, Eloise Keeling & David Chatelet, 2019 DOI: 10.1007/7651_2019_223 Type: bookChapter The role of high-fat diet and oxidative stress in driving the structural and functional deficits associated with Age-related Macular Degeneration Eloise Keeling, 2019 Type: thesis A convenient protocol for establishing a human cell culture model of the outer retina. Savannah A. Lynn, Eloise Keeling, Jennifer Dewing, David Johnston, Anton M. Page, Angela Cree, David Tumbarello, Tracey Newman, Andrew Lotery & J. Arjuna Ratnayaka, 2018, F1000Research, 7 DOI: 10.12688/f1000research.15409.1 Type: article Lysosomal impairment in the Retinal Pigment Epithelium (RPE) - a pathway of damage in the ageing retina Eloise Keeling, David Johnston, David Chatelet, David Tumbarello, Andrew Lotery & J. Arjuna Ratnayaka, 2018, Investigative Ophthalmology & Visual Science, 59 , 4487 Type: conference Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE Savannah Lynn, Gareth Ward, Eloise Keeling, Jenny Scott, Angela J. Cree, David A. Johnston, Anton Page, Enrique Cuan Urquizo, Atul Bhaskar, Martin C. Grossel, David A. Tumbarello, Tracey A. Newman, Andrew J. Lotery & J. Arjuna Ratnayaka, 2017, Tissue and Cell, 49(4), 447-460 DOI: 10.1016/j.tice.2017.06.003 Type: article The complexities underlying age-related macular degeneration- could Amyloid beta play an important role? Savannah Lynn, Eloise Keeling, Rosie Munday, Gagandeep Gabha, Helen Griffiths, Andrew Lotery & J. Arjuna Ratnayaka, 2017, Neural Regeneration Research, 12(4), 538-548 DOI: 10.4103/1673-5374.205083 Type: article The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2) Georgia Taylor-Walker, Savannah A. Lynn, Eloise Keeling, Rosie Munday, David Johnston, Anton Page, Jennifer A. Scott, Srinivas Goverdhan, Andrew J. Lotery & Janaka Ratnayaka, 2016, Experimental Eye Research, 153, 110-121 DOI: 10.1016/j.exer.2016.10.013 Type: article Pagination Previous page Previous 1 2 3