Anti-CD66
Using Targeted Radiotherapy delivered by a Radio-labelled Anti-CD66 Monoclonal Antibody with high dose melphalan compared to melphalan alone, prior to Autologous Stem Cell Transplantation for Multiple Myeloma.
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ARGO
A phase II Study of Atezolizumab with Rituximab, Gemcitabine and Oxaliplatin in patients with relapsed or refractory Diffuse Large B-Cell Lymphoma who are not candidates for High Dose Therapy
ATAFUTI
Alternative Treatments of Adult Female Urinary Tract Infection: a double blind, placebo controlled, factorial randomised trial of Uva ursi and open pragmatic trial of ibuprofen.
BREATHE
A controlled study of the effectiveness of breathing retraining exercises taught by a physiotherapist by either instructional DVD or by face-to-face sessions in the management of asthma in adults.
COAST
A placebo controlled study to gather initial information on whether aspirin reduces hearing loss/ototoxicity for patients receiving cisplatin chemotherapy.
CONTRACT
CONservative TReatment of Appendicitis in Children – a randomised controlled Trial (feasibility)
COPPI
A multicentre randomised controlled trial comparing the efficacy of a specialist and a generic parenting programme for the treatment of preschool ADHD.
EORTC 40983
Pre and Post-operative chemotherapy with oxaliplatin 5FU/LV V surgery alone if resectable liver metastases from colorectal origin—Phase III study
EPOC B
An exploratory study to investigate the optimal scheduling of chemotherapy in patients with operable colorectal liver metastases.
FACS
A randomised controlled trial to assess the cost-effectiveness of intensive versus no scheduled follow-up in patients who have undergone resection for colorectal cancer with curative intent.
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FORECAST
Fractional Flow Reserve Derived from Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain.
Gem-TIP
Phase I/II multicentre trial of salvage chemotherapy with Gem-TIP for relapsed germ cell cancer.
HATRIC
Herbal Alternative Treatment (Pelargonium) for lower Respiratory tract Infections with Cough in adults
Hip 'OP
A study to assess the effect of timing of surgical intervention on the occurrence of Avascular Necrosis in children with Developmental Dysplasia of the Hip - Early Treatment versus Intentionally Delayed Treatment.
ICE
A Phase II trial of the addition of Ipilimumab to Carboplatin and Etoposide Chemotherapy for the first line treatment of Extensive Stage Small Cell Lung Cancer
IELSG-19
Multicenter randomised trial of chlorambucil versus chlorambucil plux rituximab versus rituximab alone in extranodal marginal zone B-Cell lymphoma of mucosa associated lymphoid tissue (MALT lymphoma).
IELSG-26
This prospective multi-centre cohort study has been designed to investigate the diagnostic and prognostic utility of PET scan in primary mediastinal lymphoma.
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IELSG-32
A randomized phase II trial for immunocompetent patients with newly diagnosed primary CNS lymphoma.
IELSG-42
An international phase II trial in patients with systemic B-cell lymphoma with central nervous system involvement at diagnosis or relapse (MARIETTA regimen).
MENOS4
A multicentre randomised controlled trial of a breast care nurse delivered cognitive behavioural therapy (CBT) intervention to reduce the impact of hot flushes in women with breast cancer.
Neo-AEGIS
Neoadjuvant and adjuvant chemotherapy (Investigator’s choice Modified MAGIC or FLOT regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction
New EPOC
An open-label randomised trial, comparing OxMdG / IrMdG chemotherapy versus OxMdG / IrMdG chemotherapy plus Cetuximab.
PCV 13 in ALL
Investigating the clinical use of 13-valent pneumococcal conjugate vaccine (PCV13, Prevenar-13) in childhood Acute Lymphoblastic Leukaemia.
ProCAID
An open label phase I/randomised, double blind phase II study in metastatic castration resistant Prostate Cancer of AZD5363 In combination with Docetaxel and prednisolone chemotherapy.
SAFA
A pragmatic multicentre double-blind randomised superiority trial to investigate the clinical and cost-effectiveness of spironolactone for moderate or severe persistent acne in women.
SAKK 08/11
A phase III trial investigating Orteronel maintenance therapy in patients with metastatic castration resistant prostate cancer and non-progressive disease after first-line docetaxel therapy.
SCHRIFT
Short Chemo RadioImmunotherapy in Follicular Lymphoma Trial of 90Y Ibritumomab tiuxetan (Zevalin) as therapy for first and second relapse in Follicular Lymphoma.
SPIRE
A phase Ib/randomised IIa open label clinical trial combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer.
SPUtNIk
A prospective, observational study to assess the accuracy and cost effectiveness of dynamic contrast enhanced computed tomography in the characterisation of Solitary Pulmonary Nodules.
Trans EPOC
Investigating the molecular predictors of response in metastatic colorectal cancer.
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