Research project

J Nicoll art/pg2006/4

Lead researchers:

Professor James Nicoll
Other researchers:

Professor Delphine Boche,

Emeritus Professor Clive Holmes
Research funder:

Alzheimers Research UK
Status:

Not active

Staff

Lead researchers

Professor James Nicoll

Connect with James

Email: J.Nicoll@soton.ac.uk

Other researchers

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

Neuroimmunology and neurodegeneration
Immunophenotyping immune cells
Human brain pathology

Connect with Delphine

Email: D.Boche@soton.ac.uk

Emeritus Professor Clive Holmes

Connect with Clive

Email: C.Holmes@soton.ac.uk

Research outputs

Brain volume change following anti-amyloid β immunotherapy for Alzheimer's disease: amyloid-removal-related pseudo-atrophy

Christopher R.S. Belder, Delphine Boche, James Nicoll, Zane Jaunmuktane, Henrik Zetterberg, Jonathan M. Schott, Frederik Barkhof & Nick C. Fox, 2024, The Lancet Neurology, 23(10), 1025-1034

DOI: 10.1016/S1474-4422(24)00335-1

Type: review

No replicating evidence for anti-amyloid-β autoantibodies in cerebral amyloid angiopathy-related inflammation

Emma van den Berg, Rian Roelofs, Lieke Jakel, Steven M. Greenberg, Andreas Charidimou, Ellis S. van Etten, Delphine Boche, Catharina J.M. Klijn, Floris H.B.M. Schreuder, Bea Kuiperij & Marcel Verbeek, 2024, Annals of Clinical and Translational Neurology

Type: article

Histopathological correlates of hemorrhagic lesions on ex vivo MRI in immunized Alzheimer’s disease cases.

Ashley Scherlek, Mariel Kozberg, James Nicoll, Valentina Perosa, Whitney Freeze, Louise van der Weerd, Brian Bacskai, Steven Greenberg, Matthew Frosch, Delphine Boche & Susanne van Veluw, 2022, Brain Communications

Type: article

Understanding cause and effect in Alzheimer's pathophysiology: implications for clinical trials

Delphine Boche & James Nicoll, 2020, Neuropathology and Applied Neurobiology

Type: review

Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study

Diana, Karina Franco Bocanegra, Bethany George, Laurie C. Lau, Clive Holmes, James A.R. Nicoll & Delphine Boche, 2019, Acta Neuropathologica Communications, 7(1), 174

DOI: 10.1186/s40478-019-0828-x

Type: article

Persistent neuropathological effects 14 years following amyloid-β immunisation in Alzheimer’s disease

James A.R. Nicoll, George R. Buckland, Charlotte H. Harrison, Anton Page, Scott Harris, Seth Love, James W. Neal, Clive Holmes & Delphine Boche, 2019, Brain, 142(7), 2113-2126

DOI: 10.1093/brain/awz142

Type: article

Brief communication. A novel method to visualise the three-dimensional organisation of the human cerebral cortical vasculature

C H Harrison, G R Buckland, S E Brooks, D A Johnston, D S Chatelet, A K L Liu, S M Gentleman, D Boche & J A R Nicoll, 2018, Journal of Anatomy, 1-6

DOI: 10.1111/joa.12805

Type: article