Publications

Explore our research outputs and impact in-depth.

Developing a 3D bone model of osteosarcoma to investigate cancer mechanisms and evaluate treatments

Hannah L. Smith, Stephen A. Beers, Janos M. Kanczler & Juliet C. Gray, 2024, The FASEB Journal, 38(24)

DOI: 10.1096/fj.202402011R

Type: article

A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma

Min Zhang, Aleksandra Bzura, Essa Y. Baitei & Gareth Griffiths, 2024, Nature Communications, 15(1)

DOI: 10.1038/s41467-024-49842-5

Type: article

Serum immunoglobulin and the threshold of Fc receptor-mediated immune activation

Hannah Bauer-Smith, Abigail S.L. Sudol, Stephen A. Beers & Max Crispin, 2023, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1867(11)

DOI: 10.1016/j.bbagen.2023.130448

Type: article

Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc

Osman Dadas, Joel D. Allen, Sarah L. Buchan, Jinny H. Kim, H.T. Claude Chan, C. Ian Mockridge, Patrick J. Duriez, Anne Rogel, Max Crispin & Aymen Al-Shamkhani, 2023, Frontiers in Immunology, 14

DOI: 10.3389/fimmu.2023.1252274

Type: article

Reducing affinity as a strategy to boost immunomodulatory antibody agonism

Xiaojie Yu, Christian Orr, H.T. Claude Chan, Sonya James, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Jonathan W. Essex, Ivo Tews, Martin J. Glennie & Mark Cragg, 2023, Nature, 614(7948), 539-547

DOI: 10.1038/s41586-022-05673-2

Type: article

Fc-γ receptor-mediated crosslinking co-defines the immunostimulatory activity of anti-human CD96 antibodies

Anne Rogel, Fathima M Ibrahim, Stephen Thirdborough, Florence Renart-Depontieu, Charles Birts, Sarah Buchan, Xavier Preville, Emma King & Aymen Al-Shamkhani, 2022, JCI Insight, 7(19)

DOI: 10.1172/jci.insight.158444

Type: article

A randomized, double-blind, biomarker-selected, phase II clinical trial of maintenance poly ADP-ribose polymerase inhibition with rucaparib following chemotherapy for metastatic urothelial carcinoma

Simon J. Crabb, Syed Hussain, Eileen Soulis, Samantha Hinsley, Laura Dempsey, Avril Trevethan, YeePei Song, Jim Barber, John Frew, Joanna Gale, Guy Faust, Susannah Brock, Ursula McGovern, Omi Parikh, Deborah Enting, Santhanam Sundar, Gihan Ratnayake, Kathryn Lees, Alison J Birtle, Thomas Powles & Robert J Jones, 2022, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 41(1), 54-64

DOI: 10.1200/JCO.22.00405

Type: article