Research group

Bioinformatics and Genomics

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Using advanced omics technologies to explore the complex biology of cancers.

Part of Engineering, Medicine

About

We look at cancers at whole tumour, spatial and single-cell levels. 天发娱乐棋牌_天发娱乐APP-官网|下载 integrated approaches include genomic, transcriptomic and epigenomic sequencing technologies. These techniques allow us to discover new therapeutic targets and biomarkers.

Computational biology and bioinformatics

Central to our genomics research is our expertise in computational biology and bioinformatics. 天发娱乐棋牌_天发娱乐APP-官网|下载 computational biologists and bioinformaticians develop and apply advanced computational tools to analyse large biological and clinical datasets from our omics studies.

Cancer genomics

We aim to unravel the genetic drivers of tumorigenesis and cancer progression, making use of comprehensive DNA sequencing techniques including:

whole exome sequencing (WES)
whole genome sequencing (WGS)
both short-read and long-read targeted sequencing

We employ RNA sequencing approaches such as:

bulk RNA sequencing
bulk miRNA sequencing
single-cell RNA sequencing (scRNA)
long-read RNA sequencing

These approaches allow us to interpret gene expression profiles and identify dysregulated pathways critical to cancer. To understand the epigenetic regulation of cancer pathways, we use methods such as:

DNA methylation profiling
ATAC-seq
miRNA sequencing

天发娱乐棋牌_天发娱乐APP-官网|下载 research has a particular focus on Chronic Lymphocytic Leukaemia and Splenic Marginal Zone Lymphoma. 天发娱乐棋牌_天发娱乐APP-官网|下载 research also extends beyond B cell cancers to include ongoing collaborations with groups investigating sarcomas and other solid tumours.