We are recruiting healthy male and female volunteers, aged between 18 and 55 years, to participate in a new research study funded by the Medical Research Council. The study is investigating the effects of established drug treatments in a new experimental model of anxiety (inhalation of air enriched with 7.5 per cent?carbon dioxide – CO2).

You will complete a detailed health screening interview to assess?your eligibility. You will then be randomised?to take either a two week?course of duloxetine?(a licensed treatment for anxiety), or a two week course of a placebo tablet. You will then be asked to attend a single?three hour testing session on the last day of the treatment phase at which you will be asked to complete some questionnaires assessing mood and anxiety, and two computerised tasks whilst inhaling a safe gas mixture of air enriched with 7.5 per cent?CO2 for twenty minutes, and normal air for twenty minutes.

Participants will receive ?100 for their involvement.

If you are interested in finding out more please email Dr Susan Bamford and Verity Pinkney on co2study@soton.ac.uk?to request a copy of the study information sheet and to arrange a pre-screening interview.